Splice is a 2009 science fiction horror film directed by Vincenzo Natali and starring Adrien Brody, Sarah Polley, and Delphine Chanéac. The story concerns experiments in genetic engineering being done by a young scientific couple, who attempt to introduce human DNA into their work of splicing animal genes resulting in the creation of a human–animal hybrid.[3] Guillermo del Toro, Don Murphy, and Joel Silver are credited as executive producers of this film. Theatrically released on June 4, 2010, the film received generally positive reviews from critics but was commercially unsuccessful, and grossed just $27.1 million against a $30 million production budget.

Two young rebellious scientists are told by their employers to halt groundbreaking work that has seen them produce new creatures with medical benefits by splicing together multiple organisms’ DNA. They decide to secretly continue their work, but this time splicing in human DNA.